Brain & Breathing


Research. Papers

Montandon G and Slutsky AS. Solving the Opioid Crisis: Respiratory Depression by Opioids as Critical Endpoint. 2019. CHEST. Accepted May 15, 2019

Satkunendrarajah K, Karadimas S, Laliberte A, Montandon G, Felhing M. Cervical excitatory neurons sustain breathing after spinal cord injury. 2018. Nature. In press.

Montandon G, Wu H, Liu H, Vu MT, Orser BA, Horner RL. δ-Subunit Containing GABAA Receptors Modulate Respiratory Networks. Scientific Reports. 2017 Dec 22;7(1):18105.

Salam MT, Montandon G, Genov R, Devinsky O, Del Campo M, Carlen PL. 2017. Mortality with brainstem seizures from focal 4-aminopyridine-induced recurrent hippocampal seizures. Epilepsia. 2017.

Horton GA, Fraigne JJ, Torontali ZA, Snow MB, Lapierre JL, Liu H, Montandon G, Peever JH, Horner RL. Activation of a Medullary Respiratory Motor Circuit by Remote Control. Scientific Reports, January 2017.

Montandon G, Ren J, Wickman K, Greer JJ. Horner RL. 2016. G-protein inwardly-rectifying potassium (GIRK) channels mediate opioid-induced respiratory depression. Anesthesiology. 124(3), 641-50.

Montandon G, Liu H, Horner RL. 2016. Contribution of the respiratory network to rhythm and motor output revealed by modulation of GIRK channels, somatostatin and neurokinin-1 receptors. Scientific Reports. Sep 7;6:32707.

Montandon G, Cushing SL, Campbell F, Propst EJ, Horner RL, Narang I. 2016. Distinct cortical signatures associated with sedation and respiratory rate depression by morphine in a pediatric populatione. Anesthesiology. Nov;125(5):889-903.

Poublanc J, Crawley AP, Sobczyk O, Montandon G, Sam K, Mandell DM, Dufort P, Venkatraghavan L, Duffin J, Mikulis DJ, Fisher JA. 2015. Measuring cerebrovascular reactivity: the dynamic response to a step hypercapnic stimulus. J Cereb Blood Flow Metab. 35(11):1746-56.

Montandon G, Horner RL. 2013. State-dependent role of hyperpolarization-activated Na+/K+ and persistent Na+ currents in respiratory rhythm generation in vivo. Journal of Neuroscience. 33(20):8716-28.

Montandon G, Qin W, Liu H, Ren J, Greer JJ, Horner RL. 2011. PreBötzinger complex neurokinin-1 receptor-expressing neurons mediate opioid-induced respiratory depression. The Journal of Neuroscience. 31: 1292-1301.

Montandon G, Horner RL, Kinkead R, Bairam A. 2009. Caffeine in the neonatal period induces long-lasting changes in sleep and breathing in adult rats. The Journal of Physiology. 587(22):5493-507.

Kinkead R, Montandon G, Horner RL, Bairam A. 2009. Neonatal maternal separation disrupts regulation of sleep and breathing in adult male rats. Sleep. 32(12):1611-20.

Bairam A, Montandon G, Joseph V, Lajeunesse Y, Kinkead R. 2009. Enhancement of the breathing frequency response to hypoxia by neonatal caffeine treatment in adult male rats: the role of testosterone. Respiratory, Physiology and Neurobiology. 165(2-3):261-5.

Montandon G, Bairam A, Kinkead R. 2008. Neonatal caffeine induces sex-specific developmental plasticity of the hypoxic ventilatory response in adult rats. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 295(3), R922-34.

Montandon G, Kinkead R, Bairam A. 2007. Disruption of adenosinergic modulation of the respiratory control system by neonatal caffeine in young rats: role of adenosine A1 and A2A receptors. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 292(4), R1621-31.

Montandon G, Bairam A, Kinkead R. 2006. Long term consequences of neonatal caffeine on ventilation, occurrence of apneas, and hypercapnic chemoreflex of male and female rats. Pediatric Research. 59, 519-24.

deBisschop C, Montandon G, Guénard H. 2006. Expiratory muscles modulate negative expiratory pressure-induced flow during muscular exercise ». Respiratory, Physiology & Neurobiology. 154(3), 453-66.


Nagappa M, Weingarten TN, Montandon G, Sprung J, Chung F. Opioids, respiratory depression, and sleep-disordered breathing. Best Pract Res Clin Anaesthesiol. 2017 Dec;31(4):469-485.

Montandon G, and Horner RL. 2014. The preBötzinger Complex is/is not essential for the respiratory depression following administration of opioid analgesics. Journal of Physiology. 592(Pt 6):1159-62.

Montandon G, Bairam A, Kinkead R. 2008. Adenosinergic modulation of breathing and caffeine-induced developmental plasticity. Special Issue of Respiratory Physiology and Neurobiology: Neurochemistry of Respiratory Control. 164 (1-2), 87-95.