Exciting new paper about respiratory recovery after spinal cord injury recently published in Nature

April 11, 2019

Dysfunctional breathing is the main cause of morbidity and mortality after traumatic injury of the cervical spinal cord1,2 and often necessitates assisted ventilation, thus stressing the need to develop strategies to restore breathing. Cervical interneurons that form synapses on phrenic motor neurons, which control the main inspiratory muscle, can modulate phrenic motor output and diaphragmatic function3,4,5. Here, using a combination of pharmacogenetics and respiratory physiology assays in different models of spinal cord injury, we show that mid-cervical excitatory interneurons are essential for the maintenance of breathing in mice with non-traumatic cervical spinal cord injury, and are also crucial for promoting respiratory recovery after traumatic spinal cord injury.

Recent Posts

An addiction museum at the University of Jianghan in China

December 02, 2019 Read More

A Medscape article about our opioid research…

November 13, 2019

https://www.medscape.com/viewarticle/920880  

Read More

iBest Lecture on Opioids…

October 02, 2019

Don’t miss the iBEST VISITING LECTURER SERIES: Understanding opioid-induced respiratory depression to identify safe opioid pain therapies. Gaspard Montandon, PhD. 2nd Floor ALLAN WATERS FAMILY AUDITORIUM Friday Oct. 4 at 1pm. Li Ka Shing Knowledge Institute  

Read More