Brain & Breathing


Research Articles

Rousseau JP, Furdui A, Silveira Scarpellini CD, Horner RL, Montandon G. 2023. Medullary tachykinin precursor 1 neurons promote rhythmic breathing.  Elife. 2023 Jul 17;12:e85575. doi: 10.7554/eLife.85575.

Furdui A, Da Silveira Scarpellini C, and Montandon G. 2023. Fentanyl-induced respiratory depression and locomotor hyperactivity are mediated by µ-opioid receptors expressed in somatostatin-negative neurons. eNeuro. Jun 28;10(6):ENEURO.0035-23.2023. doi: 10.1523/ENEURO.0035-23.2023

Danaf J, da Silveira Scarpellini C, Montandon G. βγ G-proteins, but not regulators of G-protein signaling 4, modulate opioid-induced respiratory rate depression. Frontiers in Physiology. 2023 Apr 6;14:1043581. doi: 10.3389/fphys.2023.1043581. eCollection 2023. PMID: 37089428.

Tamir-Hostovsky L, Ivanovska J, Parajón E, Patel R, Wang H, Biouss G, Ivanovski N, Belik J, Pierro A, Montandon G, Gauda EB. 2023. Maturational effect of leptin on CO2 chemosensitivity in newborn rats. Pediatric Research. 2023 Apr 25. doi: 10.1038/s41390-023-02604-3. PMID: 37185965

Aggarwal JA, Liu WY, Montandon G, Liu H, Hughes SW, Horner RL.  2020. Measurement and State-Dependent Modulation of Hypoglossal Motor Excitability and Responsivity In-Vivo. Scientific Reports. 2020 Jan 17;10(1):550

Zaig S, da Silveira Scarpellini C, Montandon G. Respiratory depression and analgesia by opioid drugs in freely-behaving larval zebrafish. eLife. Mar 15;10:e63407.

Montandon G, Horner RL. Electrocortical changes associating sedation and respiratory depression by the opioid analgesic fentanyl.  Scientific Reports. 2019 Oct 1;9(1):14122.

Montandon G and Slutsky AS. Solving the Opioid Crisis: Respiratory Depression by Opioids as Critical Endpoint. 2019. CHEST. S0012-3692(19)31185-7.


Satkunendrarajah K, Karadimas S, Laliberte A, Montandon G, Felhing M. Cervical excitatory neurons sustain breathing after spinal cord injury. 2018. Nature. 562(7727):419-422.

Montandon G, Wu H, Liu H, Vu MT, Orser BA, Horner RL. δ-Subunit Containing GABAA Receptors Modulate Respiratory Networks. Scientific Reports. 2017 Dec 22;7(1):18105.

Salam MT, Montandon G, Genov R, Devinsky O, Del Campo M, Carlen PL. 2017. Mortality with brainstem seizures from focal 4-aminopyridine-induced recurrent hippocampal seizures. Epilepsia. 2017.

Horton GA, Fraigne JJ, Torontali ZA, Snow MB, Lapierre JL, Liu H, Montandon G, Peever JH, Horner RL. Activation of a Medullary Respiratory Motor Circuit by Remote Control. Scientific Reports, January 2017.

Montandon G, Ren J, Wickman K, Greer JJ. Horner RL. 2016. G-protein inwardly-rectifying potassium (GIRK) channels mediate opioid-induced respiratory depression. Anesthesiology. 124(3), 641-50.

Montandon G, Liu H, Horner RL. 2016. Contribution of the respiratory network to rhythm and motor output revealed by modulation of GIRK channels, somatostatin and neurokinin-1 receptors. Scientific Reports. Sep 7;6:32707.

Montandon G, Cushing SL, Campbell F, Propst EJ, Horner RL, Narang I. 2016. Distinct cortical signatures associated with sedation and respiratory rate depression by morphine in a pediatric populatione. Anesthesiology. Nov;125(5):889-903.

Poublanc J, Crawley AP, Sobczyk O, Montandon G, Sam K, Mandell DM, Dufort P, Venkatraghavan L, Duffin J, Mikulis DJ, Fisher JA. 2015. Measuring cerebrovascular reactivity: the dynamic response to a step hypercapnic stimulus. J Cereb Blood Flow Metab. 35(11):1746-56.

Montandon G, Horner RL. 2013. State-dependent role of hyperpolarization-activated Na+/K+ and persistent Na+ currents in respiratory rhythm generation in vivo. Journal of Neuroscience. 33(20):8716-28.

Montandon G, Qin W, Liu H, Ren J, Greer JJ, Horner RL. 2011. PreBötzinger complex neurokinin-1 receptor-expressing neurons mediate opioid-induced respiratory depression. The Journal of Neuroscience. 31: 1292-1301.

Montandon G, Horner RL, Kinkead R, Bairam A. 2009. Caffeine in the neonatal period induces long-lasting changes in sleep and breathing in adult rats. The Journal of Physiology. 587(22):5493-507.

Kinkead R, Montandon G, Horner RL, Bairam A. 2009. Neonatal maternal separation disrupts regulation of sleep and breathing in adult male rats. Sleep. 32(12):1611-20.

Bairam A, Montandon G, Joseph V, Lajeunesse Y, Kinkead R. 2009. Enhancement of the breathing frequency response to hypoxia by neonatal caffeine treatment in adult male rats: the role of testosterone. Respiratory, Physiology and Neurobiology. 165(2-3):261-5.

Montandon G, Bairam A, Kinkead R. 2008. Neonatal caffeine induces sex-specific developmental plasticity of the hypoxic ventilatory response in adult rats. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 295(3), R922-34.

Montandon G, Kinkead R, Bairam A. 2007. Disruption of adenosinergic modulation of the respiratory control system by neonatal caffeine in young rats: role of adenosine A1 and A2A receptors. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 292(4), R1621-31.

Montandon G, Bairam A, Kinkead R. 2006. Long term consequences of neonatal caffeine on ventilation, occurrence of apneas, and hypercapnic chemoreflex of male and female rats. Pediatric Research. 59, 519-24.

deBisschop C, Montandon G, Guénard H. 2006. Expiratory muscles modulate negative expiratory pressure-induced flow during muscular exercise ». Respiratory, Physiology & Neurobiology. 154(3), 453-66.


Stucke AG, Levitt ES, Montandon G. Editorial: Opioid-induced respiratory depression: neural circuits and cellular pathways. Front Physiol. 2023 Dec 20;14:1348910.

Jean-Philippe Rousseau, Gaspard Montandon. 2022. Neural Mechanisms Regulating Opioid-Induced Respiratory Depression and Therapeutic Strategies to Alleviate the Respiratory Side-Effects of Opioid Drugs. Chapter in
Book Control of Breathing during Sleep. From Bench to Bedside. Taylor and Francis Group.

Ahmad A, Ahmad R, Meteb M, Ryan CM, Leung RS, Montandon G, Luks V, Kendzerska T. The relationship between opioid use and obstructive sleep apnea: A systematic review and meta-analysis. Sleep Medicine Reviews. 2021 Jan 21;58:101441.

Montandon G. The Pathophysiology of Opioid-induced Respiratory Depression. Handbook of Clinical of Neurology. 2022. 188:339- 55. PMID: 35965031.

Nagappa M, Weingarten TN, Montandon G, Sprung J, Chung F. Opioids, respiratory depression, and sleep-disordered breathing. Best Pract Res Clin Anaesthesiol. 2017 Dec;31(4):469-485.

Montandon G, and Horner RL. 2014. The preBötzinger Complex is/is not essential for the respiratory depression following administration of opioid analgesics. Journal of Physiology. 592(Pt 6):1159-62.

Montandon G, Bairam A, Kinkead R. 2008. Adenosinergic modulation of breathing and caffeine-induced developmental plasticity. Special Issue of Respiratory Physiology and Neurobiology: Neurochemistry of Respiratory Control. 164 (1-2), 87-95.