Brain & Breathing


Research Articles

Aggarwal JA, Liu WY, Montandon G, Liu H, Hughes SW, Horner RL. Measurement and State-Dependent Modulation of Hypoglossal Motor Excitability and Responsivity In-Vivo. Scientific Reports. 2020 Jan 17;10(1):550

Zaig S, da Silveira Scarpellini C, Montandon G. Respiratory depression and analgesia by opioid drugs in freely-behaving larval zebrafish. eLife. Mar 15;10:e63407.

Montandon G, Horner RL. Electrocortical changes associating sedation and respiratory depression by the opioid analgesic fentanyl.  Scientific Reports. 2019 Oct 1;9(1):14122.

Montandon G and Slutsky AS. Solving the Opioid Crisis: Respiratory Depression by Opioids as Critical Endpoint. 2019. CHEST. S0012-3692(19)31185-7.


Satkunendrarajah K, Karadimas S, Laliberte A, Montandon G, Felhing M. Cervical excitatory neurons sustain breathing after spinal cord injury. 2018. Nature. 562(7727):419-422.

Montandon G, Wu H, Liu H, Vu MT, Orser BA, Horner RL. δ-Subunit Containing GABAA Receptors Modulate Respiratory Networks. Scientific Reports. 2017 Dec 22;7(1):18105.

Salam MT, Montandon G, Genov R, Devinsky O, Del Campo M, Carlen PL. 2017. Mortality with brainstem seizures from focal 4-aminopyridine-induced recurrent hippocampal seizures. Epilepsia. 2017.

Horton GA, Fraigne JJ, Torontali ZA, Snow MB, Lapierre JL, Liu H, Montandon G, Peever JH, Horner RL. Activation of a Medullary Respiratory Motor Circuit by Remote Control. Scientific Reports, January 2017.

Montandon G, Ren J, Wickman K, Greer JJ. Horner RL. 2016. G-protein inwardly-rectifying potassium (GIRK) channels mediate opioid-induced respiratory depression. Anesthesiology. 124(3), 641-50.

Montandon G, Liu H, Horner RL. 2016. Contribution of the respiratory network to rhythm and motor output revealed by modulation of GIRK channels, somatostatin and neurokinin-1 receptors. Scientific Reports. Sep 7;6:32707.

Montandon G, Cushing SL, Campbell F, Propst EJ, Horner RL, Narang I. 2016. Distinct cortical signatures associated with sedation and respiratory rate depression by morphine in a pediatric populatione. Anesthesiology. Nov;125(5):889-903.

Poublanc J, Crawley AP, Sobczyk O, Montandon G, Sam K, Mandell DM, Dufort P, Venkatraghavan L, Duffin J, Mikulis DJ, Fisher JA. 2015. Measuring cerebrovascular reactivity: the dynamic response to a step hypercapnic stimulus. J Cereb Blood Flow Metab. 35(11):1746-56.

Montandon G, Horner RL. 2013. State-dependent role of hyperpolarization-activated Na+/K+ and persistent Na+ currents in respiratory rhythm generation in vivo. Journal of Neuroscience. 33(20):8716-28.

Montandon G, Qin W, Liu H, Ren J, Greer JJ, Horner RL. 2011. PreBötzinger complex neurokinin-1 receptor-expressing neurons mediate opioid-induced respiratory depression. The Journal of Neuroscience. 31: 1292-1301.

Montandon G, Horner RL, Kinkead R, Bairam A. 2009. Caffeine in the neonatal period induces long-lasting changes in sleep and breathing in adult rats. The Journal of Physiology. 587(22):5493-507.

Kinkead R, Montandon G, Horner RL, Bairam A. 2009. Neonatal maternal separation disrupts regulation of sleep and breathing in adult male rats. Sleep. 32(12):1611-20.

Bairam A, Montandon G, Joseph V, Lajeunesse Y, Kinkead R. 2009. Enhancement of the breathing frequency response to hypoxia by neonatal caffeine treatment in adult male rats: the role of testosterone. Respiratory, Physiology and Neurobiology. 165(2-3):261-5.

Montandon G, Bairam A, Kinkead R. 2008. Neonatal caffeine induces sex-specific developmental plasticity of the hypoxic ventilatory response in adult rats. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 295(3), R922-34.

Montandon G, Kinkead R, Bairam A. 2007. Disruption of adenosinergic modulation of the respiratory control system by neonatal caffeine in young rats: role of adenosine A1 and A2A receptors. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 292(4), R1621-31.

Montandon G, Bairam A, Kinkead R. 2006. Long term consequences of neonatal caffeine on ventilation, occurrence of apneas, and hypercapnic chemoreflex of male and female rats. Pediatric Research. 59, 519-24.

deBisschop C, Montandon G, Guénard H. 2006. Expiratory muscles modulate negative expiratory pressure-induced flow during muscular exercise ». Respiratory, Physiology & Neurobiology. 154(3), 453-66.


Ahmad A, Ahmad R, Meteb M, Ryan CM, Leung RS, Montandon G, Luks V, Kendzerska T. The relationship between opioid use and obstructive sleep apnea: A systematic review and meta-analysis. Sleep Medicine Reviews. 2021 Jan 21;58:101441.

Nagappa M, Weingarten TN, Montandon G, Sprung J, Chung F. Opioids, respiratory depression, and sleep-disordered breathing. Best Pract Res Clin Anaesthesiol. 2017 Dec;31(4):469-485.

Montandon G, and Horner RL. 2014. The preBötzinger Complex is/is not essential for the respiratory depression following administration of opioid analgesics. Journal of Physiology. 592(Pt 6):1159-62.

Montandon G, Bairam A, Kinkead R. 2008. Adenosinergic modulation of breathing and caffeine-induced developmental plasticity. Special Issue of Respiratory Physiology and Neurobiology: Neurochemistry of Respiratory Control. 164 (1-2), 87-95.