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Being a part of research that can directly and meaningfully impact people's lives keeps Shenhab excited about her volunteer work in Dr. Gaspard Montandon’s lab at the Keenan Centre for Biomedical Science. She helps the lab use basic science research to find a solution to the #opioidcrisis. This week, we’ll be recognizing volunteers at St. Michael’s who make a difference at the hospital and in our research institutes. * “The time you dedicate to research is worth it because you're working towards a greater goal. St. Michael's has a vibrant research community where everyone is always willing to share more about their research and help you with yours!” * Thank you Shenhab – your support in research makes a difference to the work we do.
Congrats Shenhab for winning the second place for second place at the UTSC Undergraduate Research Poster Forum
Dysfunctional breathing is the main cause of morbidity and mortality after traumatic injury of the cervical spinal cord1,2 and often necessitates assisted ventilation, thus stressing the need to develop strategies to restore breathing. Cervical interneurons that form synapses on phrenic motor neurons, which control the main inspiratory muscle, can modulate phrenic motor output and diaphragmatic function3,4,5. Here, using a combination of pharmacogenetics and respiratory physiology assays in different models of spinal cord injury, we show that mid-cervical excitatory interneurons are essential for the maintenance of breathing in mice with non-traumatic cervical spinal cord injury, and are also crucial for promoting respiratory recovery after traumatic spinal cord injury.